Othman Iylia Ajmal, Zahedi Farah Dayana, Husain Salina
Department of Otorhinolaryngology Head and Neck Surgery, Kulliyyah of Medicine, IUniversity Malaysia, Kuantan, Pahang, Malaysia.
Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Case Rep Med. 2020 Jul 30;2020:2610597. doi: 10.1155/2020/2610597. eCollection 2020.
Breast cancer metastases to the base of the skull with concomitant infiltration into the paranasal sinuses and nasopharynx are exceptionally rare with only small numbers of reported literatures. Greenberg et al. in 1981 described five clinical syndromes with regards to the base of skull metastases and the clinical presentation of each syndrome related to its anatomical location. Often, metastases to the base of the skull remain asymptomatic until the lesion has increased to a considerable size causing bony destruction and impingement to the surrounding structures. When involving the paranasal sinuses or nasopharynx, the most common presenting symptoms mimic those of rhinosinusitis and, hence, may delay the accurate diagnosis. We are reporting a case of base of skull metastasis from breast carcinoma, 23 years after the primary diagnosis. To the best of our knowledge, our case is the first case to report latent metastasis of more than 20 years.
乳腺癌转移至颅底并同时浸润至鼻窦和鼻咽极为罕见，仅有少量文献报道。1981年，格林伯格等人描述了与颅底转移相关的五种临床综合征，每种综合征的临床表现与其解剖位置相关。通常，颅底转移在病变增大到相当大的尺寸导致骨质破坏并压迫周围结构之前一直无症状。当累及鼻窦或鼻咽时，最常见的症状类似鼻窦炎，因此可能会延迟准确诊断。我们报告一例乳腺癌颅底转移病例，该病例在初次诊断23年后出现转移。据我们所知，我们的病例是首例报告超过20年的潜伏转移病例。
