Palta J R, Biggs P J, Hazle J D, Huq M S, Dahl R A, Ochran T G, Soen J, Dobelbower R R, McCullough E C
Department of Radiation Oncology, University of Florida Health Science Center, Gainesville 32610-0385, USA.
Int J Radiat Oncol Biol Phys. 1995 Oct 15;33(3):725-46. doi: 10.1016/0360-3016(95)00280-C.
Intraoperative radiation therapy (IORT) is a treatment modality whereby a large single dose of radiation is delivered to a surgically open, exposed cancer site. Typically, a beam of megavoltage electrons is directed at an exposed tumor or tumor bed through a specially designed applicator system. In the last few years, IORT facilities have proliferated around the world. The IORT technique and the applicator systems used at these facilities vary greatly in sophistication and design philosophy. The IORT beam characteristics vary for different designs of applicator systems. It is necessary to document the existing techniques of IORT, to detail the dosimetry data required for accurate delivery of the prescribed dose, and to have a uniform method of dose specification for cooperative clinical trials. The specific charge to the task group includes the following: (a) identify the multidisciplinary IORT team, (b) outline special considerations that must be addressed by an IORT program, (c) review currently available IORT techniques, (d) describe dosimetric measurements necessary for accurate delivery of prescribed dose, (e) describe dosimetric measurements necessary in documenting doses to the surrounding normal tissues, (f) recommend quality assurance procedures for IORT, (g) review methods of treatment documentation and verification, and (h) recommend methods of dose specification and recording for cooperative clinical trials.
术中放射治疗（IORT）是一种治疗方式，即向手术暴露的癌灶给予大剂量单次放射。通常，一束兆伏级电子通过专门设计的施源器系统指向暴露的肿瘤或肿瘤床。在过去几年中，IORT设备在全球范围内迅速增加。这些设备所使用的IORT技术和施源器系统在复杂性和设计理念上差异很大。不同设计的施源器系统，其IORT射线束特性也有所不同。有必要记录现有的IORT技术，详细说明准确给予规定剂量所需的剂量测定数据，并制定用于合作临床试验的统一剂量规范方法。该任务组的具体职责如下：（a）确定多学科IORT团队；（b）概述IORT计划必须考虑的特殊因素；（c）审查目前可用的IORT技术；（d）描述准确给予规定剂量所需的剂量测定；（e）描述记录周围正常组织剂量所需的剂量测定；（f）推荐IORT的质量保证程序；（g）审查治疗记录和验证方法；（h）推荐用于合作临床试验的剂量规范和记录方法。
