Harik S I, Lust W D, Jones S C, Lauro K L, Pundik S, LaManna J C
Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio USA.
J Appl Physiol (1985). 1995 Jul;79(1):136-40. doi: 10.1152/jappl.1995.79.1.136.
Hypobaric hypoxia at one-half atmospheric pressure for 3 wk was reported to increase the brain capillary density and glucose transport at the blood-brain barrier in the adult rat. We examined the metabolic concomitants of these alterations in rats subjected to the same hypoxic insult. Hypoxic rats increased brain glucose and lactate concentrations and decreased brain glycogen. However, hypoxia had no significant effects on regional brain levels of ATP and phosphocreatine or on intracellular pH, indicating successful adaptation to the hypoxic insult. 2-Deoxyglucose studies showed that hypoxia increased the regional metabolic rate for glucose by 10-40%. These results indicate increased glycolysis in the hypoxic rat brain, which probably underlies the increased density of glucose transporters in brain microvessels and the increased blood-to-brain glucose influx in hypoxia.
据报道，成年大鼠在半个大气压下进行3周的低压缺氧会增加脑毛细血管密度，并增强血脑屏障处的葡萄糖转运。我们研究了遭受相同缺氧损伤的大鼠中这些改变的代谢伴随情况。缺氧大鼠的脑葡萄糖和乳酸浓度升高，脑糖原减少。然而，缺氧对脑内ATP和磷酸肌酸的区域水平或细胞内pH没有显著影响，表明成功适应了缺氧损伤。2-脱氧葡萄糖研究表明，缺氧使葡萄糖的区域代谢率提高了10%-40%。这些结果表明缺氧大鼠脑内糖酵解增加，这可能是脑微血管中葡萄糖转运体密度增加以及缺氧时血脑葡萄糖流入增加的基础。
