患有肾病性贫血的氮质血症患者血清中红细胞集落形成细胞的抑制剂。

Inhibitors of erythroid colony forming cells in sera of azotemic patients with anemia of renal disease.

Rege A B, Ohno Y, Barona J, Fisher J W

Proc Clin Dial Transplant Forum. 1978;8:189-93.

Abstract

The plasma clot method of McLeod, et al8 was used to study the inhibitors of erythroid colony forming cells (CFU-E and BFU-E) in sera of patients with anemia of uremia. 2. Compared to sera from hematologically normal human subjects, sera from undialyzed patients with anemia of uremia produced a significant inhibition of CFU-E and BFU-E. 3. A marked reduction in the inhibitor(s) of CFU-E was seen in sera of 3 out of 4 patients following 16 wks of intermittent hemodialysis. 4. Creatinine, guanidine, guanidinosuccinic acid and guanidinobutyric acid had no effect on the erythroid colony forming cells. 5. Together with the relative erythropoietin deficiency, inhibitor(s) of the erythroid progenitor cell compartment may play a major role in the mechanism of the anemia of renal insufficiency.

摘要

采用麦克劳德等人的血浆凝块法研究尿毒症贫血患者血清中红系集落形成细胞（CFU-E和BFU-E）的抑制剂。2. 与血液学正常人类受试者的血清相比，未透析的尿毒症贫血患者的血清对CFU-E和BFU-E产生了显著抑制作用。3. 4例患者中有3例在进行16周间歇性血液透析后，其血清中CFU-E抑制剂明显减少。4. 肌酐、胍、胍基琥珀酸和胍基丁酸对红系集落形成细胞无影响。5. 与相对促红细胞生成素缺乏一起，红系祖细胞区室的抑制剂可能在肾功能不全贫血的机制中起主要作用。