Brown A E, Vahey M T, Zhou S Y, Chung R C, Ruiz N M, Hofheinz D, Lane J R, Mayers D L
Walter Reed Army Institute of Research, Henry M. Jackson Foundation for the Advancement of Military Research, Rockville, MD 20850, USA.
J Infect Dis. 1995 Oct;172(4):1091-5. doi: 10.1093/infdis/172.4.1091.
To better understand the biologic meaning and potential clinical utility of p24 antigen measurements in human immunodeficiency virus (HIV) infection, p24 antigen and antibody and HIV RNA were quantitated in parallel. Specimens (n = 311) were analyzed from 74 participants in a zidovudine treatment study. Parallel antigen and RNA measurements revealed the frequent occurrence of two types of discordant results. First, p24 antigen was often not detected in samples with high antibody levels even when > 10(6) RNA copies/mL were present. Second, in specimens in which p24 antigen was detected, the concentration was greater than expected on the basis of HIV RNA values. These results suggest that optimal use of serum p24 antigen values will require consideration of both specific antibody levels and non-virion associated antigen.
为了更好地理解人类免疫缺陷病毒（HIV）感染中p24抗原检测的生物学意义及潜在临床应用价值，对p24抗原、抗体及HIV RNA进行了平行定量检测。从齐多夫定治疗研究的74名参与者中分析了311份样本。抗原与RNA的平行检测发现了两种常见的不一致结果。首先，即使样本中HIV RNA拷贝数>10⁶/mL且抗体水平较高时，p24抗原也常未被检测到。其次，在检测到p24抗原的样本中，其浓度高于基于HIV RNA值预期的浓度。这些结果表明，要想最佳利用血清p24抗原值，需要同时考虑特异性抗体水平和非病毒体相关抗原。
