Muangman V, Viseshsindh V, Ratana-Olarn K, Buadilok S
Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 1995 Jun;78(6):310-3.
One hundred consecutive cases with renal stones less than 3 cm in size and normal renal function underwent ESWL from January to March 1994. Out of these, 50 were given Andrographis paniculata tablets (250 mg), 4 tablests tid, 25 were given cotrimoxazole 2 tablets bid and 25 received norfloxacin 200 mg bid, started immediately after ESWL and continued for 5 days. All tolerated the treatment well and none had complications. At one month follow-up, pre- and post-ESWL pyuria, hematuria and proteinuria among the Andrographis paniculata group were 84, 58, 72, 40, 52, 22 per cent; the cotrimoxazole group 88, 64, 84, 64, 56, 44 per cent and the norfloxacin group 92, 56, 72, 40 per cent and 56, 28 per cent respectively. The results showed that post ESWL pyuria and hematuria in patients receiving Andrographis peniculata were reduced to 0.69 and 0.55 time of pre ESWL value. We think that this herbal medicine is beneficial in the treatment of post ESWL urinary tract infection. Besides the herbal drug given to eighteen previously sulfa sensitized patients resulted in no allergic reaction.
1994年1月至3月，对100例肾结石直径小于3cm且肾功能正常的患者进行了体外冲击波碎石术（ESWL）。其中，50例患者服用穿心莲片（250mg），每日3次，每次4片；25例患者服用复方新诺明，每日2次，每次2片；25例患者服用诺氟沙星，每日2次，每次200mg。所有药物均在ESWL术后立即开始服用，持续5天。所有患者对治疗耐受性良好，均未出现并发症。在1个月的随访中，穿心莲组ESWL术前、术后的脓尿、血尿和蛋白尿发生率分别为84%、58%、72%、40%、52%、22%；复方新诺明组分别为88%、64%、84%、64%、56%、44%；诺氟沙星组分别为92%、56%、72%、40%、56%、28%。结果显示，服用穿心莲的患者ESWL术后脓尿和血尿发生率分别降至术前的0.69倍和0.55倍。我们认为这种草药对治疗ESWL术后尿路感染有益。此外，给予18例既往对磺胺类药物过敏的患者该草药后未出现过敏反应。
