Fulop L D, Barrett A D, Titball R W
Chemical and Biological Defence Establishment, Porton Down, Salisbury, UK.
J Gen Virol. 1995 Sep;76 ( Pt 9):2317-21. doi: 10.1099/0022-1317-76-9-2317.
Banzi is a mosquito borne flavivirus which belongs to the Uganda S serocomplex. No nucleotide sequence data have previously been reported from any virus of this serocomplex. We have determined the nucleotide sequence of the NS5 gene from Banzi virus and the predicted amino acid sequence was elucidated. Previously identified conserved RNA polymerase, methyltransferase and flavivirus NS5 amino acid motifs were present in the Banzi virus NS5 protein. These data add to the evidence for the functional importance of the regions. The encoded amino acid sequence was compared with the predicted amino acid sequence of other flavivirus NS5 proteins. Analysis of these sequences suggested that Banzi virus is most closely related to the mosquito-borne flaviviruses and, in particular, yellow fever virus. This pattern of similarity is in accordance with the previously suggested serological classification of flaviviruses.
班齐病毒是一种由蚊子传播的黄病毒，属于乌干达S血清复合体。此前尚未有该血清复合体中任何病毒的核苷酸序列数据报道。我们已确定了班齐病毒NS5基因的核苷酸序列，并阐明了预测的氨基酸序列。先前鉴定出的保守RNA聚合酶、甲基转移酶和黄病毒NS5氨基酸基序存在于班齐病毒NS5蛋白中。这些数据进一步证明了这些区域的功能重要性。将编码的氨基酸序列与其他黄病毒NS5蛋白的预测氨基酸序列进行了比较。对这些序列的分析表明，班齐病毒与蚊子传播的黄病毒关系最为密切，尤其是黄热病毒。这种相似模式与先前提出的黄病毒血清学分类一致。
