Miyake Y, Tsuruda K, Okuda K, Iwamoto Y, Suginaka H
Department of Microbiology, Hiroshima University School of Dentistry, Japan.
J Periodontal Res. 1995 Jul;30(4):290-3. doi: 10.1111/j.1600-0765.1995.tb02136.x.
We re-evaluated several antibiotics including newer ones, for their in vitro killing activity, as well as their inhibitory activity, against clinical isolates of periodontopathic bacteria. Tetracyclines were active against Porphyromonas gingivalis, and were highly active against Prevotella intermedia, but demonstrated only a low killing activity against Actinobacillus actinomycetemcomitans. Rokitamycin, a new macrolide, and clindamycin were highly active against P. gingivalis and P. intermedia, but showed very weak killing activity against A. actinomycetemcomitans. Quinolones demonstrated excellent bactericidal activity against A. actinomycetemcomitans, and good inhibitory and bactericidal activity against P. gingivalis and P. intermedia. Metronidazole had an activity almost equivalent to quinolones against P. gingivalis and P. intermedia; but it was the least active against A. actinomycetemcomitans.
我们重新评估了几种抗生素，包括新型抗生素，检测它们对牙周病原菌临床分离株的体外杀菌活性以及抑制活性。四环素对牙龈卟啉单胞菌有活性，对中间普氏菌有高活性，但对伴放线放线杆菌的杀菌活性较低。新型大环内酯类抗生素罗他霉素和克林霉素对牙龈卟啉单胞菌和中间普氏菌有高活性，但对伴放线放线杆菌的杀菌活性非常弱。喹诺酮类对伴放线放线杆菌显示出优异的杀菌活性，对牙龈卟啉单胞菌和中间普氏菌有良好的抑制和杀菌活性。甲硝唑对牙龈卟啉单胞菌和中间普氏菌的活性几乎与喹诺酮类相当；但对伴放线放线杆菌的活性最低。
