Sheehan D V, Raj B A, Trehan R R, Knapp E L
Institute for Research in Psychiatry, University of South Florida, Tampa 33613.
Int Clin Psychopharmacol. 1993 Nov;8 Suppl 2:63-77. doi: 10.1097/00004850-199311002-00010.
The role of serotonin in psychiatry has been the focus of speculation for several decades. The literature since 1966 is reviewed (and referenced) and five organizing questions are identified: (1) What are the major hypotheses regarding the involvement of the serotonin system in panic disorder? (2) Is there a serotonin system defect associated with panic disorder? (3) Is a serotonin system defect the cause of panic disorder? (4) Are the 5-HT1A agonists and the 5-HT2 antagonists effective in this condition? (5) Are serotonin selective uptake inhibitors (SSUIs) effective in panic disorder via the serotonin system or some other mechanism? Though the role of the serotonin system in panic disorder and social phobia is uncertain there is increasing agreement that SSUIs effectively treat panic disorder but further double-blind placebo-controlled studies are needed.
几十年来，血清素在精神病学中的作用一直是推测的焦点。本文回顾（并引用）了1966年以来的文献，并确定了五个组织性问题：（1）关于血清素系统参与惊恐障碍的主要假说是哪些？（2）是否存在与惊恐障碍相关的血清素系统缺陷？（3）血清素系统缺陷是惊恐障碍的病因吗？（4）5-HT1A激动剂和5-HT2拮抗剂在这种情况下有效吗？（5）血清素选择性摄取抑制剂（SSUIs）通过血清素系统还是其他某种机制对惊恐障碍有效？尽管血清素系统在惊恐障碍和社交恐惧症中的作用尚不确定，但越来越多的人一致认为，SSUIs能有效治疗惊恐障碍，但仍需要进一步的双盲安慰剂对照研究。
