Gu X X, Spaepen M, Raeymaekers P, Guo C, Fagard R, Amery A, Lijnen P, Cassiman J J
Center for Human Genetics, University of Leuven, Belgium.
J Hum Hypertens. 1995 Jul;9(7):553-5.
The aim of the present study was to investigate whether the HLA class II polymorphisms contributes to the susceptibility to essential hypertension in the Belgian population. For this purpose we studied 120 hypertensive patients and 168 normotensive controls by means of a PCR-SSO assay. No significant difference in allele and genotype frequencies of the DRB and DPB1 loci could be found between the two groups. We concluded that essential hypertension as a multifactorial and heterogeneous disease cannot be associated with one of the HLA class II DRB and DPB1 alleles in Belgian patients.
本研究的目的是调查HLA II类基因多态性是否与比利时人群原发性高血压的易感性有关。为此，我们通过聚合酶链反应-序列特异性寡核苷酸探针分析（PCR-SSO）研究了120例高血压患者和168例血压正常的对照者。两组之间DRB和DPB1位点的等位基因和基因型频率未发现显著差异。我们得出结论，原发性高血压作为一种多因素异质性疾病，在比利时患者中不能与HLA II类DRB和DPB1等位基因之一相关联。
