Zamani M G, De Hert M, Spaepen M, Hermans M, Marynen P, Cassiman J J, Peuskens J
Center for Human Genetics, University of Leuven, Belgium.
Am J Med Genet. 1994 Dec 15;54(4):372-7. doi: 10.1002/ajmg.1320540417.
In the present study the HLA-DRB and DPB1 alleles as well as CD4 and CD3 polymorphisms were tested in 100 Belgian schizophrenic patients and 204 controls. Our results indicate a significant negative association of the DPB1 0101 allele with schizophrenia (relative risk [RR] = 0.27). Furthermore a significant positive and negative association could be noticed for the CD4A4 allele and CD4A7/A8 genotype, respectively (RR 1.79 and 0.47, respectively). These findings suggest that some contribution of HLA class II and CD4 genes to an autoimmune-like pathogenesis in schizophrenia might exist.
在本研究中，对100例比利时精神分裂症患者和204名对照者进行了HLA - DRB和DPB1等位基因以及CD4和CD3多态性检测。我们的结果表明，DPB1 0101等位基因与精神分裂症存在显著负相关（相对风险[RR]=0.27）。此外，CD4A4等位基因和CD4A7/A8基因型分别存在显著正相关和负相关（RR分别为1.79和0.47）。这些发现提示，HLA II类基因和CD4基因可能对精神分裂症的自身免疫样发病机制有一定作用。
