Yates M S, Askey E A, Wilmot S E, Bowmer C J
J Pharm Pharmacol. 1985 Jul;37(7):486-90. doi: 10.1111/j.2042-7158.1985.tb03045.x.
Vascular reactivity in-vivo and in-vitro was examined in rats with acute renal failure produced by bilateral nephrectomy or intramuscular glycerol injection. Bilaterally nephrectomized rats displayed enhanced pressor responses to noradrenaline and angiotensin. However, the contractile responses to noradrenaline, angiotensin and potassium chloride of aortic rings and portal vein segments from nephrectomized rats were not significantly different from the responses obtained in vessels from sham-operated controls. Rats with glycerol-induced ARF which were pretreated with indomethacin had significantly lower pressor responses to noradrenaline and angiotensin than similarly treated control animals. Aortic rings from glycerol-injected rats produced significantly smaller contractions to noradrenaline than preparations from controls. This difference was not abolished by incubation of vessels with indomethacin. The findings suggest that the absence of kidneys or the presence of damaged renal tissue and not uraemia itself have pronounced but opposite effects on vascular reactivity. The depression of vascular reactivity in glycerol-induced ARF does not appear to be a result of increased production of prostaglandins.
对通过双侧肾切除或肌肉注射甘油诱导急性肾衰竭的大鼠进行了体内和体外血管反应性研究。双侧肾切除的大鼠对去甲肾上腺素和血管紧张素的升压反应增强。然而，肾切除大鼠主动脉环和门静脉段对去甲肾上腺素、血管紧张素和氯化钾的收缩反应与假手术对照组血管的反应无显著差异。用吲哚美辛预处理的甘油诱导急性肾衰竭大鼠对去甲肾上腺素和血管紧张素的升压反应明显低于同样处理的对照动物。甘油注射大鼠的主动脉环对去甲肾上腺素的收缩反应明显小于对照组的标本。用吲哚美辛孵育血管并不能消除这种差异。这些发现表明，肾脏缺失或受损肾组织的存在而非尿毒症本身对血管反应性有显著但相反的影响。甘油诱导急性肾衰竭中血管反应性的降低似乎不是前列腺素产生增加的结果。
