Wlodarska I, De Wolf-Peeters C, Michaux L, Mecucci C, Verhoef G, Cassiman J J, Van den Berghe H
Centre for Human Genetics, University of Leuven, Belgium.
Leukemia. 1995 Oct;9(10):1685-8.
Anaplastic large cell lymphoma (ALCL) expressing the CD30 antigen is an uncommon subtype of non-Hodgkin's lymphoma characterized by distinct morphological and clinical features. The recurrent chromosomal abnormality found in these tumours is a t(2;5)(p23;q35) which has been detected in a minority of these cases, predominantly with a T cell immunophenotype. We report here a CD30 positive null cell type ALCL case cytogenetically characterized by a new type of t(2;5) translocation with distinct breakpoints at 2q37 and 5q31. FISH with a panel of 5q specific DNA probes applied in this case allowed for a mapping of a 5q31 breakpoint region between the locus for IL-3 (proximally) and CI5-56 probe (distally). These results point to a localization of unknown gene(s) on the long arm of chromosome 5 that, in addition to the NPM gene at 5q35, may be involved in the pathogenesis of some CD30+ ALCL.
表达CD30抗原的间变性大细胞淋巴瘤（ALCL）是非霍奇金淋巴瘤的一种罕见亚型，具有独特的形态学和临床特征。这些肿瘤中发现的复发性染色体异常是t(2;5)(p23;q35)，在少数此类病例中被检测到，主要是T细胞免疫表型。我们在此报告一例CD30阳性裸细胞型ALCL病例，其细胞遗传学特征为一种新型的t(2;5)易位，在2q37和5q31处有不同的断点。在该病例中使用一组5q特异性DNA探针进行荧光原位杂交（FISH），能够将5q31断点区域定位在IL-3基因座（近端）和CI5-56探针（远端）之间。这些结果表明，除了位于5q35的NPM基因外，5号染色体长臂上未知基因的定位可能参与了某些CD30+ ALCL的发病机制。
