Ott G, Bastian B C, Katzenberger T, Decoteau J F, Kalla J, Rosenwald A, Weissinger F, Ott M M, Kadin M E, Müller-Hermelink H K
Pathologisches Institut, University of Würzburg, Germany.
Br J Haematol. 1998 Jan;100(1):187-90. doi: 10.1046/j.1365-2141.1998.00531.x.
Cytogenetic investigations were performed in a case of a nodal malignant non-Hodgkin's lymphoma. Histopathological analysis from an involved lymph node as well as from a skin biopsy revealed a lymphohistiocytic variant of CD30-positive anaplastic large cell lymphoma (ALCL). A t(2;5)(p23;q35) chromosome translocation could be observed in all metaphases analysed. This finding was confirmed both by RT-PCR analysis of the NPM/ALK fusion protein and by positive staining with the p80(NPM/ALK) antibody. To the best of our knowledge, this is the first report of a t(2;5) documented by classic cytogenetics in the lymphohistiocytic variant of ALCL.
对1例淋巴结恶性非霍奇金淋巴瘤进行了细胞遗传学研究。对受累淋巴结以及皮肤活检组织进行的组织病理学分析显示为CD30阳性间变性大细胞淋巴瘤（ALCL）的淋巴组织细胞变异型。在所有分析的中期相中均观察到t(2;5)(p23;q35)染色体易位。通过对NPM/ALK融合蛋白的RT-PCR分析以及用p80(NPM/ALK)抗体进行阳性染色，均证实了这一发现。据我们所知，这是经典细胞遗传学记录的ALCL淋巴组织细胞变异型中t(2;5)的首例报告。
