Santos P M, Williams S L, Covey J
Division of Otolaryngology, Southern Illinois University School of Medicine, Springfield 62794, USA.
Laryngoscope. 1995 Oct;105(10):1061-5. doi: 10.1288/00005537-199510000-00010.
The potential therapeutic effect of hyperbaric oxygen (HBO) after rat peroneal nerve crush was evaluated. Animals were given 100% oxygen at 2.5 atmosphere absolute for 90 minutes twice daily for 1 week and then once daily for 1 week. Edema increased in crushed nerves compared with control nerves, but no effect was associated with the administration of HBO. Gait analysis demonstrated injury at 1, 7, and 14 days after nerve crush, but no difference was found at 22 and 28 days after injury (analysis of variance: P < .001, 10 animals per group). Eight weeks after injury, nerve stimulation and muscle force measurements were 114 g for the injured group and 146 g for the control group (P < .001). There were no HBO-associated changes in gait parameter or nerve/muscle force measurements. This study demonstrated that rat peroneal nerve crush injury causes acute intraneural edema and temporary decrement of gait parameters. Elicited nerve stimulation demonstrated persistent loss of force 4 weeks after normalization of gait, but no HBO effect.
评估了高压氧（HBO）对大鼠腓总神经挤压伤后的潜在治疗效果。动物每天两次在绝对压力2.5个大气压下给予100%氧气，持续90分钟，共1周，然后每天一次，持续1周。与对照神经相比，挤压伤神经中的水肿增加，但给予HBO没有相关作用。步态分析显示在神经挤压伤后1天、7天和14天有损伤，但在损伤后22天和28天未发现差异（方差分析：P <.001，每组10只动物）。损伤8周后，损伤组的神经刺激和肌肉力量测量值为114克，对照组为146克（P <.001）。在步态参数或神经/肌肉力量测量方面没有与HBO相关的变化。本研究表明，大鼠腓总神经挤压伤会导致急性神经内水肿和步态参数的暂时下降。诱发的神经刺激显示，步态恢复正常4周后力量持续丧失，但HBO没有效果。
