Haapaniemi T, Nylander G, Kanje M, Dahlin L
Department of Plastic Surgery, Hand Surgery and Burns, Faculty of Health Sciences, University Hospital, Linköping, Sweden.
Exp Neurol. 1998 Feb;149(2):433-8. doi: 10.1006/exnr.1997.6745.
The effect of hyperbaric oxygen (HBO) treatment on regeneration of the rat sciatic nerve was studied. The sciatic nerve was crushed with a pair of pliers and the animals were either left untreated or subjected to a series of 45-min exposures to 100% O2 at 3.3 atm absolute pressure at 0, 4, and 8 h postoperatively and then every 8 h. Regeneration was evaluated using the pinch-reflex test at 3, 4, or 5 days following surgery and with neurofilament staining at 4 days. The regeneration distances at all time points were significantly longer in animals exposed to hyperbaric oxygen treatment independent of the evaluation procedure. A short initial period of the same HBO treatment schedule, with no more treatments after 25 h, appeared as effective as when treatments were maintained being given every 8 h until evaluation. We conclude that HBO treatment stimulates axonal outgrowth following a nerve crush lesion.
研究了高压氧（HBO）治疗对大鼠坐骨神经再生的影响。用钳子夹伤坐骨神经，术后0、4和8小时，然后每8小时对动物进行一系列45分钟的100%氧气暴露，绝对压力为3.3个大气压，未治疗的动物作为对照。在术后3、4或5天使用捏反射试验评估再生情况，并在术后4天进行神经丝染色。无论评估程序如何，接受高压氧治疗的动物在所有时间点的再生距离均显著更长。相同的HBO治疗方案，在25小时后不再进行治疗，其短时间的初始治疗期与每8小时持续治疗直至评估时的效果相同。我们得出结论，HBO治疗可刺激神经挤压损伤后的轴突生长。
