Nagataki S, Nakashima M, Akino K, Ohtsuru A, Namba H, Kiriyama T, Ito M, Sekine I, Yamashita S
First Department of Internal Medicine, Nagasaki University School of Medicne, Japan.
Miner Electrolyte Metab. 1995;21(1-3):148-51.
Parathyroid hormone-related peptide (PTHrP) expression is associated with the histological type in pituitary tumor, but not in thyroid carcinoma. However invasive and metastatic tumors showed intense PTHrP staining in both pituitary and thyroid tumors. Analysis of the established metastatic rat pituitary tumor cell line showed that PTHrP plays a crucial role in in vivo cell proliferation closely related to worsening of malignant transformation and neovascularization in a paracrine fashion.
甲状旁腺激素相关肽（PTHrP）的表达与垂体肿瘤的组织学类型相关，但与甲状腺癌无关。然而，侵袭性和转移性肿瘤在垂体瘤和甲状腺瘤中均显示出强烈的PTHrP染色。对已建立的转移性大鼠垂体肿瘤细胞系的分析表明，PTHrP以旁分泌方式在体内细胞增殖中起关键作用，这与恶性转化和新血管形成的恶化密切相关。
