Widmer J, Féray J C, Bovier P, Hilleret H, Raffin Y, Chollet D, Gaillard J M, Garay R
Institutions Universitaires de Psychiatrie de Genève, Switzerland.
Neuropsychobiology. 1995;32(1):13-8. doi: 10.1159/000119206.
The Vmax of erythrocyte sodium-magnesium exchange was measured for the first time in 63 patients suffering from affective disorders and compared to that in 33 healthy subjects. Depressed patients had a significantly higher Vmax (215 +/- 13 vs. 151 +/- 14 mumol/l.cells/h; p < 0.005; mean +/- SEM). This tendency was conserved after division of the 63 patients into three clinical subgroups according to the DSM-III-R criteria. Thirty-four patients from this panel were divided into three subgroups according to the chemical class of the antidepressant drug used and were followed up during a 3-month period of drug treatment. Mood improvement over the 3-month period was associated with a slow increase in Vmax of Na/Mg exchange (delta increase approximately 25 mumol/l.cells/h), except in the subgroup of patients treated with non-tricyclic antidepressants (n = 8). These results are consistent with the previously reported link between high erythrocyte magnesium content and affective disorders. Indeed, enhanced Na/Mg exchange Vmax, which probably results from an increased number of transport units per cell, contributes to the normalization of red blood cell magnesium content correlated with mood improvement.
首次对63例情感障碍患者的红细胞钠-镁交换最大速率（Vmax）进行了测量，并与33名健康受试者的该指标进行了比较。抑郁症患者的Vmax显著更高（分别为215±13与151±14μmol/升·细胞/小时；p<0.005；均值±标准误）。根据《精神疾病诊断与统计手册》第三版修订版（DSM-III-R）标准将63例患者分为三个临床亚组后，这一趋势依然存在。该组中的34例患者根据所使用的抗抑郁药的化学类别分为三个亚组，并在3个月的药物治疗期间进行随访。除了使用非三环类抗抑郁药治疗的患者亚组（n = 8）外，在3个月期间情绪改善与钠/镁交换Vmax的缓慢增加相关（增加量约为25μmol/升·细胞/小时）。这些结果与先前报道的红细胞镁含量高与情感障碍之间的联系一致。实际上，钠/镁交换Vmax的增强可能是由于每个细胞中转运单位数量增加所致，这有助于使与情绪改善相关的红细胞镁含量恢复正常。
