Fujii Y, Takahashi A, Yoshimoto T
Department of Intravascular Neurosurgery, Kohnan Hospital, Sendai, Japan.
Neurosurg Rev. 1995;18(1):7-13. doi: 10.1007/BF00416470.
Of 455 cases of ruptured intracranial aneurysm treated with radical surgery from January 1987 to March 1992, 19 cases with high grade symptomatic vasospasm were treated by percutaneous transluminal balloon angioplasty (PTA). The indication for PTA was high grade symptomatic vasospasm which does not respond to conservative medical treatment. Of the 36 segments of vasospastic arteries, severe vasospasm (angiographical constriction more than 50% of diameter on admission) was observed in 67%. PTA dilated these vasospastic arteries significantly (diameter of more than 75% of diameter on admission) in 83%. Follow up angiography revealed neither recurrence of vasospasm nor chronic atherosclerotic changes. Clinical improvement within 24 hours after PTA was observed in 63% of cases (7 of 17 cases with consciousness disturbance, 5 of 16 cases with motor weakness and one of 7 cases with aphasia). Outcomes at the time of discharge were excellent in 10 cases, good in 3, fair in 4, and lethal in 2. SPECT study before and after PTA confirmed improvement of cerebral blood flow in 3 out of 5 cases investigated. PTA for high grade symptomatic vasospasm after subarachnoid hemorrhage is considered an effective treatment method for the patient who does not respond to medical therapy. Immediate improvement of angiographical and clinical findings were frequently observed immediately after PTA. Exact indication and timing of PTA should be postulated after much more cases have been treated with this methal.
1987年1月至1992年3月期间,455例接受根治性手术治疗的颅内动脉瘤破裂患者中,19例出现重度症状性血管痉挛,接受了经皮腔内球囊血管成形术(PTA)治疗。PTA的适应证为对保守药物治疗无反应的重度症状性血管痉挛。在36段痉挛动脉中,67%观察到严重血管痉挛(入院时血管造影显示管径缩窄超过50%)。83%的患者经PTA后这些痉挛动脉显著扩张(管径超过入院时的75%)。随访血管造影显示既无血管痉挛复发也无慢性动脉粥样硬化改变。63%的患者在PTA后24小时内临床症状改善(意识障碍的17例中有7例,运动无力的16例中有5例,失语的7例中有1例)。出院时结果为优10例,良3例,中4例,死亡2例。5例接受研究的患者经PTA前后的单光子发射计算机断层扫描(SPECT)研究证实脑血流量有所改善。对于蛛网膜下腔出血后重度症状性血管痉挛,PTA被认为是对药物治疗无反应患者的一种有效治疗方法。PTA后血管造影和临床结果通常立即得到明显改善。在更多病例接受这种方法治疗后,应明确PTA的确切适应证和时机。