Gurevich P, Ben-Hur H, Czernobilsky B, Nyska A, Zuckerman A, Zusman I
Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Pathology. 1995 Apr;27(2):121-6. doi: 10.1080/00313029500169702.
The pathology of lymphoid organs in 38 low birth weight (LBW) human infants has been evaluated by morphological and morphometric features. The gestational ages of infants ranged from 22 to 32 wks and their age at death varied from 1 hr to 153 days post partum. Infants were divided into 3 groups: 1) without antigenic effects, 2) with mild (bronchopneumonia), and 3) with severe antigenic effects, mainly sepsis. In mildly affected LBW infants, the fetal type of the immune reaction was found. It continued during the period studied (till 5 mths) and was manifested in the reaction of macrophages and the transformation of lymphocytes to lymphoblasts. Reactive centres of follicles and mature plasmocytes were not found. During the first months of postnatal development, an increase in the amount of lymphocytes in the lymphoid organs and in the rate of proliferation of reticular epithelium and a decrease in the area of the cortex in the thymus were found in all infants. In severely affected infants, the number and the size of follicles in the spleen decreased significantly and the total number of cells decreased more than 3 times. Similar changes were found in lymph nodes. These changes as well as the weak reaction of the thymus are the main features of the insufficiency and fast devastation of the lymphoid system. A compensatory increase in the number of neutrophils and eosinophils in the red pulp of the spleen and lymph nodes was found after the second week.
通过形态学和形态计量学特征，对38例低出生体重（LBW）人类婴儿的淋巴器官病理学进行了评估。婴儿的胎龄为22至32周，死亡时年龄在产后1小时至153天之间。婴儿分为3组：1）无抗原影响；2）有轻度（支气管肺炎）；3）有严重抗原影响，主要是败血症。在轻度受影响的低出生体重婴儿中，发现了胎儿型免疫反应。在所研究的时期（直至5个月）内持续存在，并表现为巨噬细胞反应和淋巴细胞向淋巴母细胞的转化。未发现滤泡反应中心和成熟浆细胞。在出生后发育的最初几个月，所有婴儿的淋巴器官中淋巴细胞数量增加，网状上皮细胞增殖率增加，胸腺皮质面积减小。在严重受影响的婴儿中，脾脏中滤泡的数量和大小显著减少，细胞总数减少超过3倍。在淋巴结中也发现了类似变化。这些变化以及胸腺的弱反应是淋巴系统功能不全和快速破坏的主要特征。第二周后，在脾脏和淋巴结的红髓中发现中性粒细胞和嗜酸性粒细胞数量代偿性增加。
