de Benedictis F M, Canny G J, MacLusky I B, Levison H
Division of Respiratory Medicine, Hospital for Sick Children, Toronto.
Pediatr Pulmonol. 1995 Jun;19(6):326-9. doi: 10.1002/ppul.1950190603.
Bronchial responsiveness to isocapnic hyperventilation with cold air (CAH) and to inhaled methacholine (MCH) was compared in 17 children with bronchial asthma. The response to cold air was expressed as the percent drop in FEV1 from baseline at 4 min. after the challenge (delta % FEV1 CAH), and the response to methacholine as the provocative concentration required to reduce the FEV1 by 20% from baseline (PC20MCH). Both tests were sensitive (94%) for detecting airway hyperreactivity. There was no statistically significant relationship between delta % FEV1 CAH and the log PC20MCH (r = 0.39; P = 0.12). In clinical practice, methacholine test is easier to perform, but in the research field cold air challenge may be preferable because it avoids potential drug effects.
对17名支气管哮喘儿童比较了其支气管对冷空气等碳酸通气（CAH）和吸入乙酰甲胆碱（MCH）的反应性。冷空气反应以激发后4分钟FEV1较基线下降的百分比表示（Δ%FEV1 CAH），乙酰甲胆碱反应以使FEV1较基线降低20%所需的激发浓度表示（PC20MCH）。两种测试对检测气道高反应性均敏感（94%）。Δ%FEV1 CAH与log PC20MCH之间无统计学显著相关性（r = 0.39；P = 0.12）。在临床实践中，乙酰甲胆碱试验更容易进行，但在研究领域，冷空气激发试验可能更可取，因为它避免了潜在的药物效应。
