Wyse D G, McAnulty J H, Rahimtoola S H
Clin Cardiol. 1978 Aug;1(2):112-7. doi: 10.1002/clc.4960010211.
Prophylaxis is defined as: "measures designed to preserve health and prevent the spread of disease" (18). Two implicit parts to such a definition are first, that what is being prevented causes disease, and second, that the measure(s) proposed prevents this disease. We will briefly review the evidence that patients with rheumatic heart disease and/or prosthetic cardiac devices are at increased risk of morbidity and mortality from infection and further that antibiotics reduce this morbidity and mortality. Antibiotic prophylaxis is undertaken in patients with rheumatic heart disease and in those with prosthetic devices for two purposes: 1. prevention of reccurrences of rheumatic fever; and, 2. prevention of infective endocarditis. These are two different issues which will be discussed separately.
“旨在维护健康和预防疾病传播的措施”（18）。这一定义隐含两个部分，首先，被预防的对象会引发疾病；其次，所提议的措施能预防这种疾病。我们将简要回顾证据，即风湿性心脏病患者和/或植入心脏假体装置的患者因感染导致发病和死亡的风险增加，而且抗生素能降低这种发病和死亡风险。对风湿性心脏病患者和植入假体装置的患者进行抗生素预防有两个目的：1. 预防风湿热复发；2. 预防感染性心内膜炎。这是两个不同的问题，将分别进行讨论。
