Ward C, Jephcott A E, Hardisty C A
Postgrad Med J. 1977 Jul;53(621):353-5. doi: 10.1136/pgmj.53.621.353.
A study of twenty-five cases of prosthetic valve endocarditis suggests that the antibiotics used for perioperative prophylaxis may alter the type and antibiotic sensitivity of organisms which subsequently infect the artificial valves. Based on the results of this study, the authors have been able to modify their prophylactic regime to encompass these organisms and to predict the antibiotics most likely to be effective in the treatment of prosthetic valve endocarditis in their unit. No single prophylactic or therapeutic regime will be equally effective in all centres, but by examining the different types and sensitivities of bacteria which cause prosthetic valve endocarditis in a locality, antibiotic regimes can be chosen which best suit the local situation.
一项针对25例人工瓣膜心内膜炎病例的研究表明，用于围手术期预防的抗生素可能会改变随后感染人工瓣膜的微生物类型及抗生素敏感性。基于该研究结果，作者得以调整其预防方案，将这些微生物纳入考虑范围，并预测在其所在科室最有可能有效治疗人工瓣膜心内膜炎的抗生素。没有一种单一的预防或治疗方案在所有中心都能同样有效，但通过检查当地引起人工瓣膜心内膜炎的不同细菌类型和敏感性，可以选择最适合当地情况的抗生素方案。
