吗啉和烯丙胺类抗真菌剂的噻吩类似物——合成与生物活性
Thiophene congeners of morpholine and allylamine type antifungals--syntheses and biological activities.
作者信息
Bracher F, Papke T
机构信息
Institut für Pharmazeutische Chemie, Technische Universität Braunschweig.
出版信息
Pharmazie. 1995 Aug;50(8):525-7.
PMID:7568314
Abstract
A thiophene analogue 8 of the antifungal drug amorolfine (1) was prepared starting from the alcohol 5. In addition, congeners of naftifine, terbinafine and butenafine, in which the naphthalene ring is replaced by a branched thienylalkyl group, wee synthesized. Of the four drug analogues only compound 9, related to terbinafine, showed significant antifungal activity.
摘要
从醇5开始制备了抗真菌药物阿莫罗芬（1）的噻吩类似物8。此外，还合成了萘替芬、特比萘芬和布替萘芬的类似物，其中萘环被支链噻吩基烷基取代。在这四种药物类似物中，只有与特比萘芬相关的化合物9表现出显著的抗真菌活性。
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