Jansson L
Department of Medical Cell Biology, Uppsala University, Sweden.
Pharmacology. 1995 Jun;51(1):43-7. doi: 10.1159/000139315.
The aim of the present study was to evaluate if metformin, a biguanide used in the treatment of noninsulin-dependent diabetes, induced any changes in splanchnic circulation. For this purpose, anesthetized rats were injected intraperitoneally with saline alone (1 ml/kg BW) or metformin (15 or 30 mg/kg BW) 30 min before blood flow measurements. No effects on blood glucose or serum insulin concentrations could be discerned after administration of metformin. Both duodenal, whole pancreatic and islet blood flow were approximately doubled by the lowest dose (15 mg/kg BW) metformin. However, the higher dose (30 mg/kg BW) did not affect duodenal or pancreatic blood flow, whereas islet blood flow was markedly increased also in this group of animals. It is concluded that the blood flow to the pancreatic islets can be specifically enhanced by metformin. To what extent this contributes to the antihyperglycemic action of the drug is presently unknown.
本研究的目的是评估用于治疗非胰岛素依赖型糖尿病的双胍类药物二甲双胍是否会引起内脏循环的任何变化。为此，在测量血流量前30分钟，给麻醉大鼠腹腔注射单独的生理盐水（1毫升/千克体重）或二甲双胍（15或30毫克/千克体重）。给予二甲双胍后，未发现对血糖或血清胰岛素浓度有影响。最低剂量（15毫克/千克体重）的二甲双胍可使十二指肠、整个胰腺和胰岛的血流量增加约一倍。然而，较高剂量（30毫克/千克体重）对十二指肠或胰腺血流量没有影响，而在这组动物中胰岛血流量也显著增加。结论是二甲双胍可特异性增强胰腺胰岛的血流量。目前尚不清楚这在多大程度上有助于该药物的降糖作用。
