Jansson L, Efendic S
Department of Medical Cell Biology, Uppsala University, Sweden.
Peptides. 1995;16(7):1253-6. doi: 10.1016/0196-9781(95)00094-z.
The aim of the study was to evaluate the effects of pancreatic polypeptide (PP) on splanchnic blood flow in anesthetized rats. For this purpose, either PP dissolved in saline (225, 450, or 900 pmol/kg body weight/h) or saline alone was infused at a rate of 2 ml/h for 30 min. Immediately after the infusion the blood flow to the whole pancreas, islets, duodenum, and colon was measured with a microsphere technique. The highest dose of PP caused a small decrease in mean arterial blood pressure. The two lowest doses decreased duodenal blood flow, but did not affect the blood perfusion to the other investigated organs. The highest dose of PP decreased the blood flow to the pancreas, islets, and duodenum, did not affect colonic blood flow. No change in the fraction of whole pancreatic blood flow diverted through the islets could be seen after PP administration. It is concluded that administration of high doses of PP induces a general splanchnic vasoconstriction.
本研究的目的是评估胰多肽（PP）对麻醉大鼠内脏血流的影响。为此，将溶解于生理盐水的PP（225、450或900 pmol/kg体重/小时）或仅生理盐水以2 ml/小时的速率输注30分钟。输注后立即用微球技术测量整个胰腺、胰岛、十二指肠和结肠的血流。最高剂量的PP导致平均动脉血压略有下降。两个最低剂量降低了十二指肠血流，但不影响其他研究器官的血液灌注。最高剂量的PP降低了胰腺、胰岛和十二指肠的血流，对结肠血流无影响。给予PP后，未见通过胰岛的整个胰腺血流分数发生变化。得出的结论是，高剂量PP的给药会引起全身性内脏血管收缩。
