Seeley R J, Kaplan J M, Grill H J
Department of Psychology, University of Pennsylvania, Philadelphia 19104, USA.
Physiol Behav. 1995 Aug;58(2):245-9. doi: 10.1016/0031-9384(95)00054-m.
Meal size does not change in response to food being restricted to the stomach by occlusion of the pylorus. This result has been used as evidence for a gastric model of meal termination where feedback arising solely from the stomach is taken to underlie satiation. Such data provide support for the gastric model, however, only if the rate of gastric emptying during ingestion in the unoccluded condition is slow, such that comparable amounts of food would be found in the stomach at the end of the meal in both the pylorus-occluded and unoccluded conditions. To evaluate this tissue directly, rats were implanted with pyloric cuffs and gastric cannulas and given an intraoral intake test of a 10.5% glucose solution with either the pylorus occluded or unoccluded. At the end of each intraoral intake test, the content of the stomach was removed via the gastric cannula and it's volume and concentration measured. Occlusion of the pylorus did not change meal size, but both the volume and grams of glucose solute found in the stomach were substantially greater in the pylorus-occluded condition. These results are not consistent with the hypothesis that the stomach is the sole source of inhibitory signals that terminate a meal. Cumulative intake would appear to be accurately tracked regardless of its distribution within the digestive tract.
通过幽门闭塞将食物限制在胃内时，进餐量不会改变。这一结果被用作进餐终止的胃模型的证据，在该模型中，仅来自胃的反馈被认为是饱腹感的基础。然而，只有在未闭塞状态下摄入期间胃排空速率较慢时，这些数据才支持胃模型，这样在进餐结束时，幽门闭塞和未闭塞状态下胃中才会有相当数量的食物。为了直接评估该组织，给大鼠植入幽门套环和胃插管，并在幽门闭塞或未闭塞的情况下对10.5%的葡萄糖溶液进行经口摄入测试。在每次经口摄入测试结束时，通过胃插管取出胃内容物，并测量其体积和浓度。幽门闭塞并没有改变进餐量，但在幽门闭塞状态下，胃中发现的葡萄糖溶质的体积和克数都显著更大。这些结果与胃是终止进餐的抑制信号的唯一来源这一假设不一致。无论其在消化道内的分布如何，累积摄入量似乎都能被准确跟踪。
