Brink J A, Heiken J P, Forman H P, Sagel S S, Molina P L, Brown P C
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.
Radiology. 1995 Oct;197(1):83-8. doi: 10.1148/radiology.197.1.7568859.
To assess the potential for reduction of contrast material dose in hepatic spiral computed tomography (CT).
Four hundred eighty-seven outpatients were randomized prospectively into nine biphasic and eight uniphasic injection protocols: 75, 100, or 125 mL of 240, 300, or 350 mg of iodine per milliliter of iohexol (18-44 grams of iodine). Protocols were compared according to the maximum hepatic enhancement (MAX) and the contrast enhancement index (CEI).
Uniphasic injection was superior to biphasic injection for all protocols. No statistically significant difference in contrast enhancement was present for 38-44 grams of iodine with the uniphasic technique. Adequate enhancement thresholds (MAX > 50 HU, CEI at 30 HU > 300 HU x sec) were exceeded in more than 70% of heavy patients ( > 183 lb [83 kg]) with uniphasic injection of 38 g. For thin patients ( < 183 lb [83 kg]), uniphasic injection of 26 g produced adequate enhancement.
Contrast material dose may be reduced by up to 40% in thin patients undergoing hepatic spiral CT after uniphasic injection of contrast material; this may result in substantial cost savings.
评估在肝脏螺旋计算机断层扫描（CT）中降低造影剂剂量的可能性。
487名门诊患者被前瞻性随机分为9种双期和8种单期注射方案：每毫升碘海醇含240、300或350毫克碘的75、100或125毫升（18 - 44克碘）。根据最大肝脏强化（MAX）和对比增强指数（CEI）对各方案进行比较。
对于所有方案，单期注射均优于双期注射。单期技术使用38 - 44克碘时，对比增强无统计学显著差异。单期注射38克碘时，超过70%的肥胖患者（>183磅[83千克]）达到了足够的强化阈值（MAX > 50 HU，30 HU处的CEI > 300 HU·秒）。对于瘦患者（<183磅[83千克]），单期注射26克碘可产生足够的强化。
在肝脏螺旋CT检查中，单期注射造影剂后，瘦患者的造影剂剂量可降低多达40%；这可能会大幅节省成本。
