Rodemann H P, Bamberg M
Department of Radiotherapy, Eberhard-Karls-University, Tübingen, Germany.
Radiother Oncol. 1995 May;35(2):83-90. doi: 10.1016/0167-8140(95)01540-w.
Fibrosis is a common sequela of both cancer treatment by radiotherapy and accidental irradiation and has been described in many tissues including skin, lung, heart and liver. The underlying mechanisms of the radiation-induced fibrosis still remain to be resolved. In the present review we tried to illustrate the basic cellular mechanisms of radiation-induced fibrosis based on the newest findings arising from molecular radiobiology and cell biology. Based on these findings the cellular mechanism of radiation-induced fibrosis can be seen as a multicellular process involving various interacting cell systems in the target organ resulting in the fibrotic phenotype of the fibroblast/fibrocyte cell system.
纤维化是放射治疗癌症和意外辐射的常见后遗症，在包括皮肤、肺、心脏和肝脏在内的许多组织中都有描述。辐射诱导纤维化的潜在机制仍有待解决。在本综述中，我们试图根据分子放射生物学和细胞生物学的最新发现，阐述辐射诱导纤维化的基本细胞机制。基于这些发现，辐射诱导纤维化的细胞机制可被视为一个多细胞过程，涉及靶器官中各种相互作用的细胞系统，导致成纤维细胞/纤维细胞系统出现纤维化表型。
