Delanian S, Martin M, Housset M
Service d'oncologie-radiothérapie, hôpital Necker-Enfants-Malades Paris V, France.
Bull Cancer. 1993 Mar;80(3):192-201.
Tissue fibrosis is a non specific proliferation of connective tissue, overriding the limits of normal wound healing and essentially encountered in oncological practice as an iatrogenic pathology. This study reviews the data pertaining to the cellular and extracellular components of fibrosis and their regulation. Regulation of the fibrotic process is studied in several steps: chemotaxis and proliferation of fibroblasts, collagen metabolism, and interactions between inflammatory cells and the extracellular matrix.
组织纤维化是结缔组织的非特异性增殖，超越了正常伤口愈合的限度，在肿瘤学实践中主要作为一种医源性病理情况出现。本研究回顾了与纤维化的细胞和细胞外成分及其调节相关的数据。纤维化过程的调节在几个步骤中进行研究：成纤维细胞的趋化性和增殖、胶原蛋白代谢以及炎症细胞与细胞外基质之间的相互作用。
