染色体位置效应与转基因表达的调控
Chromosomal position effects and the modulation of transgene expression.
作者信息
Clark A J, Bissinger P, Bullock D W, Damak S, Wallace R, Whitelaw C B, Yull F
机构信息
AFRC Roslin Institute, Midlothian, Scotland, UK.
出版信息
Reprod Fertil Dev. 1994;6(5):589-98. doi: 10.1071/rd9940589.
PMID:7569038
Abstract
Chromosomal position effects can influence strongly the transcription of foreign genes in transgenic animals. This results in low frequencies and levels of gene expression and, in some cases, in aberrant patterns of expression. Strategies for overcoming these effects are described with particular reference to their application in embryonic stem cells.
摘要
染色体位置效应可强烈影响转基因动物中外源基因的转录。这会导致基因表达频率和水平较低，在某些情况下，还会出现异常的表达模式。本文特别参照其在胚胎干细胞中的应用，描述了克服这些效应的策略。
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