Moga I, Formiga F, Canet R, Pac M, Mitjavila F, Pujol R
Servicio de Medicina Interna, Hospital de Bellvitge-Princeps d'Espanya, CSU de Bellvitge.
Rev Clin Esp. 1995 Aug;195(8):530-3.
The prevalence of infection with VZV in 145 patients with SLE was investigated, with a mean follow-up of 7.6 years; its relationship with different variables, particularly with therapy of the underlying disease, was analyzed. Twenty episodes of VZV infection in 19 patients were diagnosed (13.1%). In no case was the therapeutic regime changed nor was worsening of SLE observed. There was neither dissemination of herpes nor superinfection. An increase in the number of VZV infections was observed in patients with SLE under corticosteroid therapy (p = 0.04) and particularly when drug administration was on a daily basis (p = 0.00006). Cytotoxic agents also favored the infection (p = 0.0014). VZV infection is of a benign nature in SLE and its emergence is favored by immunosuppressive agents. The risk is lower if corticosteroid administration is on alternate days. There is no need to decrease therapy for SLE.
对145例系统性红斑狼疮（SLE）患者进行了水痘-带状疱疹病毒（VZV）感染患病率的调查，平均随访7.6年；分析了其与不同变量的关系，特别是与基础疾病治疗的关系。19例患者发生了20次VZV感染（13.1%）。在任何情况下均未改变治疗方案，也未观察到SLE病情恶化。既没有疱疹播散也没有发生二重感染。在接受皮质类固醇治疗的SLE患者中观察到VZV感染数量增加（p = 0.04），尤其是每日给药时（p = 0.00006）。细胞毒药物也易引发感染（p = 0.0014）。VZV感染在SLE中性质良性，免疫抑制剂会促使其发生。隔日给予皮质类固醇时风险较低。无需减少SLE的治疗。
