Ohrn M B, Sköld C M, van Hage-Hamsten M, Sigurdardottir O, Zetterström O, Eklund A
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Respiration. 1995;62(3):136-42. doi: 10.1159/000196408.
An increased (p < 0.001) frequency of bronchial hyperreactivity (BHR) was found in sarcoidosis patients as compared with healthy volunteers. The patients had more mast cells (p < 0.001) and tryptase (p < 0.001) in their bronchoalveolar lavage fluid, but there were no differences between BHR-positive and BHR-negative patients. Furthermore, the bronchoalveolar lavage fluid concentrations of macrophages, lymphocytes, and of the soluble components albumin, fibronectin, and vitronectin were also elevated in the sarcoidosis patients, indicating an ongoing inflammation in the airways and/or in the interstitium. We observed no significant differences in the parameters when the sarcoidosis patients were subdivided into BHR, clinical activity, or chest X-ray stages. Our findings may indicate a multifactorial background to the hyperreactivity.
与健康志愿者相比，结节病患者支气管高反应性（BHR）的频率增加（p < 0.001）。患者支气管肺泡灌洗液中的肥大细胞（p < 0.001）和类胰蛋白酶（p < 0.001）更多，但BHR阳性和BHR阴性患者之间没有差异。此外，结节病患者支气管肺泡灌洗液中巨噬细胞、淋巴细胞以及可溶性成分白蛋白、纤连蛋白和玻连蛋白的浓度也升高，表明气道和/或间质存在持续炎症。当将结节病患者细分为BHR、临床活动或胸部X线分期时，我们观察到这些参数没有显著差异。我们的研究结果可能表明高反应性存在多因素背景。
