Barraviera B, Coelho K Y, Curi P R, Meira D A
Departamento de Doenças Tropicais e Diagnóstico por Imagem, Faculdade de Medicina de Botucatu - UNESP, Brasil.
Rev Inst Med Trop Sao Paulo. 1995 Jan-Feb;37(1):63-9.
Thirty-two patients bitten by venomous snakes sixteen by Bothrops spp. and sixteen by Crotalus durissus terrificus were studied. The group comprised thirty males and two females, aged eight to sixty-three years (mean 33 +/- 15). Bromsulphalein tests were increased in the majority of patients bitten by Crotalus durissus terrificus. The correlation coefficient of Spearman was positive between bromsulphalein tests and alanine aminotransferase levels, and between alanine aminotransferase and aspartate aminotransferase levels only in the Crotalus group. The only patient who died was bitten by Crotalus durissus terrificus and showed hydropic degeneration and mitochondrial injury in the liver. It was concluded that the hepatic damage might have been caused by at least two possible mechanisms: venom effect on liver mitochondria and cytokine effects on hepatocyte, specially interleukin-6.
对32例被毒蛇咬伤的患者进行了研究，其中16例被矛头蝮属蛇咬伤，16例被三色矛头蝮咬伤。该组包括30名男性和2名女性，年龄在8至63岁之间（平均33±15岁）。大多数被三色矛头蝮咬伤的患者溴磺酞钠试验结果升高。仅在三色矛头蝮组中，溴磺酞钠试验与丙氨酸转氨酶水平之间以及丙氨酸转氨酶与天冬氨酸转氨酶水平之间的斯皮尔曼相关系数为正。唯一死亡的患者被三色矛头蝮咬伤，肝脏出现水样变性和线粒体损伤。得出的结论是，肝损伤可能由至少两种可能的机制引起：毒液对肝线粒体的作用以及细胞因子对肝细胞的作用，特别是白细胞介素-6。
