Papanikolaou G, Arnold A J, Howie A J
Department of Urology, Queen Elizabeth Hospital, Birmingham, UK.
Scand J Urol Nephrol. 1995 Jun;29(2):141-6. doi: 10.3109/00365599509180554.
The distribution of Tamm-Horsfall protein, the main protein in normal urine, was studied immunohistologically in the kidneys of 70 pigs with unilateral vesico-ureteric reflux but without outflow obstruction. Strains of Escherichia coli were inoculated in the bladder. Inflammatory changes of reflux nephropathy (chronic pyelonephritis) were found in 52 pigs. There were extra-tubular deposits of Tamm-Horsfall protein in the kidneys of only 26 pigs. These deposits were small, increased in prevalence as the size of inflamed areas increased, and were not associated with deposits of the protein in glomeruli. These findings suggest that escape of Tamm-Horsfall protein from tubules and backwash into glomeruli are not major features of low pressure reflux nephropathy, unlike the findings in outflow obstruction of the lower urinary tract. There was no evidence that a reaction to Tamm-Horsfall protein was important in the pathogenesis of reflux nephropathy.
对70只患有单侧膀胱输尿管反流但无流出道梗阻的猪的肾脏进行免疫组织学研究，以观察正常尿液中的主要蛋白质——Tamm-Horsfall蛋白的分布情况。将大肠杆菌菌株接种于膀胱。在52只猪中发现了反流性肾病（慢性肾盂肾炎）的炎症变化。仅在26只猪的肾脏中发现了Tamm-Horsfall蛋白的肾小管外沉积物。这些沉积物较小，其发生率随着炎症区域大小的增加而增加，且与肾小球中该蛋白的沉积无关。这些发现表明，与下尿路流出道梗阻的情况不同，Tamm-Horsfall蛋白从小管逸出并反流至肾小球并非低压反流性肾病的主要特征。没有证据表明对Tamm-Horsfall蛋白的反应在反流性肾病的发病机制中起重要作用。
