吗氯贝胺与丙咪嗪治疗抑郁症的对照双盲试验。
A controlled double-blind trial of moclobemide and imipramine in the treatment of depression.
作者信息
Kok L P, Tsoi W F
机构信息
Department of Psychological Medicine, National University Hospital, Singapore.
出版信息
Singapore Med J. 1995 Feb;36(1):38-40.
The aim of this study is to compare the antidepressant efficacy and side effects of moclobemide with imipramine (a standard antidepressant). Moclobemide is a reversible inhibitor of monoamine-oxidase-A (RIMA) with selectivity for the MAO type A isoenzyme. Thirty-two patients who met DSM-3R criteria for major depressive episode or dysthymia were randomly assigned to receive either moclobemide or imipramine in a double-blind prospective study. The results indicated no difference in antidepressive efficacy between the two drugs, but imipramine had more anticholinergic side-effects. Neither drug had significant effects on pulse rate, blood pressure, weight changes or blood chemistry. These results were confirmed by previous studies.
本研究的目的是比较吗氯贝胺与丙咪嗪（一种标准抗抑郁药）的抗抑郁疗效及副作用。吗氯贝胺是一种对单胺氧化酶-A（RIMA）具有可逆抑制作用且对A型单胺氧化酶同工酶有选择性的药物。在一项双盲前瞻性研究中，32名符合DSM-3R标准的重度抑郁发作或心境恶劣的患者被随机分配接受吗氯贝胺或丙咪嗪治疗。结果表明，两种药物的抗抑郁疗效无差异，但丙咪嗪的抗胆碱能副作用更多。两种药物对脉搏率、血压、体重变化或血液化学指标均无显著影响。这些结果得到了先前研究的证实。
Zotero 插件