通过与大鼠DNA的序列同源性，在8p21定位区域内鉴定出人类神经元烟碱型胆碱能α2受体基因座（CHRNA2）。
Identification of the human neuronal nicotinic cholinergic alpha 2 receptor locus, (CHRNA2), within an 8p21 mapped locus, by sequence homology with rat DNA.
作者信息
Wood S, Schertzer M, Yaremko M L
机构信息
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
出版信息
Somat Cell Mol Genet. 1995 Mar;21(2):147-50. doi: 10.1007/BF02255790.
PMID:7570187
Abstract
We have identified a cosmid, at the D8S131 locus, that shows sequence homology with exon 2 of the rat gene for the neuronal nicotinic acetylcholine receptor alpha 2 subunit. A 357-bp sequence surrounding a rare cutter AscI site contains a 152-bp region of homology. The human CHRNA2 gene is therefore positioned at the D8S131 locus, which has been mapped to 8p21.
摘要
我们已经在D8S131位点鉴定出一个黏粒，它与大鼠神经元烟碱型乙酰胆碱受体α2亚基基因的外显子2具有序列同源性。围绕一个稀有切割酶AscI位点的357碱基对序列包含一个152碱基对的同源区域。因此，人类CHRNA2基因定位于D8S131位点，该位点已被定位到8p21。
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