Chevalier G, Ricard A C, Manca D
Département des Sciences Biologiques, Université du Québec, Montréal, Canada.
Toxicol Ind Health. 1994 Jan-Apr;10(1-2):43-51. doi: 10.1177/074823379401000103.
Under specific conditions, Cd can induce a prooxidant state in biological systems resulting in the peroxidation of the polyunsaturated fatty acids. We investigated in vivo this phenomenon in major target organs of Long Evans rats (12- and 36-week-old), 24 hours after being injected i.p. with a range of cadmium chloride doses (0.00, 0.05, 0.25, 1.0 or 2.5 mg Cd/kg). The measurements of the thiobarbituric acid reactive substances demonstrated that the lungs showed the highest Cd-induced LPO in the 12-week-old rats even if the liver and kidneys accumulated the greatest amounts of Cd. Cd-induced LPO as measured by TBARS assay in the 36-week-old groups was, in all organs, less pronounced even if the control levels were higher for these groups. The reasons for this age-dependent differences are not clear. Some components of the antioxidant defense system were differently modulated as a function of age. However, it is not certain whether these changes have a causative role in the induction of LPO following Cd exposure.
在特定条件下，镉可在生物系统中诱导产生促氧化状态，导致多不饱和脂肪酸发生过氧化。我们在腹腔注射一系列氯化镉剂量（0.00、0.05、0.25、1.0或2.5毫克镉/千克）24小时后，对长Evans大鼠（12周龄和36周龄）的主要靶器官中的这种现象进行了体内研究。硫代巴比妥酸反应性物质的测量结果表明，在12周龄的大鼠中，即使肝脏和肾脏积累了最多的镉，肺脏显示出最高的镉诱导脂质过氧化水平。在36周龄组中，通过硫代巴比妥酸反应物（TBARS）测定法测得的镉诱导脂质过氧化水平，在所有器官中都不那么明显，尽管这些组的对照水平较高。这种年龄依赖性差异的原因尚不清楚。抗氧化防御系统的一些成分随年龄的变化而受到不同的调节。然而，尚不确定这些变化在镉暴露后脂质过氧化的诱导过程中是否具有因果作用。
