Knaak J B
Occidental Chemical Corp, Niagara Falls, NY, USA.
Toxicol Lett. 1995 Sep;79(1-3):305-12. doi: 10.1016/0378-4274(95)03383-v.
Industry continues to promote the use of sound science in regulatory decision making. The use of decision support methodologies for hazard identification/risk assessment of toxic substances such as models employing physiologically based pharmacokinetics (PBPK) and structure-activity relationships (SAR) are recommended. A collaborative program involving government and industry is needed to further the use of these decision support methodologies. The formation of federal and state working groups is recommended. Organizations such as the Halogenated Solvents Industrial Alliance (HSIA), American Industrial Health Council (AIHC), and the Chemical Manufacturers Association (CMA) are suitable industry representatives.
行业继续推动在监管决策中运用可靠的科学。建议使用决策支持方法来识别有毒物质的危害/进行风险评估，例如采用基于生理药代动力学（PBPK）和构效关系（SAR）的模型。需要一个政府与行业合作的项目来进一步推广这些决策支持方法。建议成立联邦和州工作组。卤化溶剂工业联盟（HSIA）、美国工业卫生理事会（AIHC）和化学制造商协会（CMA）等组织是合适的行业代表。
