Popovsky M A, Whitaker B, Arnold N L
American Red Cross Blood Services, Dedham, Massachusetts, USA.
Transfusion. 1995 Sep;35(9):734-7. doi: 10.1046/j.1537-2995.1995.35996029156.x.
There are few published data on severe outcomes of the donation of blood for allogeneic or autologous use. It would be helpful if blood collectors could better characterize and/or predict the likelihood of significant complications of blood donation.
Very severe outcome (VSO) was defined as an event requiring hospitalization. Approximately 4.1 million American Red Cross whole-blood donation records (July 1993-March 1994) were reviewed for the incidence and type of VSO.
A total of 33 VSOs occurred for all donations. The incidence of VSOs for allogeneic donation was 1 (0.0005%) in 198,119 and that for autologous donation was 1 (0.006%) in 16,783 (p < 0.001). First-time donors were three times as likely to have a VSO. Donors > 40 years old had 87.9 percent of the VSOs, and donors > 60 years old had 48.5 percent. Vasovagal (66.7%) and anginal (12.1%) episodes were the most frequent complications, and 66.7 percent of reactions occurred at the blood collection site. The mean hospital stay was 1.9 days.
VSO is an infrequent complication of all types of blood donation, but its occurrence may be associated with significant morbidity and cost. VSO is nearly 12 times as likely in autologous blood donors.
关于异体或自体用血献血严重后果的已发表数据很少。如果采血者能够更好地描述和/或预测献血严重并发症的可能性，将会有所帮助。
极严重后果（VSO）定义为需要住院治疗的事件。回顾了约410万份美国红十字会全血献血记录（1993年7月至1994年3月），以了解VSO的发生率和类型。
所有献血中共发生33例VSO。异体献血的VSO发生率为198119例中的1例（0.0005%），自体献血的VSO发生率为16783例中的1例（0.006%）（p<0.001）。首次献血者发生VSO的可能性是其他人的三倍。40岁以上的献血者发生了87.9%的VSO，60岁以上的献血者发生了48.5%。血管迷走神经反应（66.7%）和心绞痛发作（12.1%）是最常见的并发症，66.7%的反应发生在采血部位。平均住院时间为1.9天。
VSO是各类献血中罕见的并发症，但其发生可能与显著的发病率和成本相关。自体献血者发生VSO的可能性几乎是异体献血者的12倍。
