Jezyna C, Mical A
Acta Biol Acad Sci Hung. 1978;29(3):227-31.
The behaviour of sialic acids and aminohexoses was examined in subacute intoxication of 60 guinea pigs with "Elocron 50 WP". Elocron 50 WP was administered in soy-bean oil emulsion by means of a stomach tube for 28 and 85 days. The daily dose was 1/3 LD50. Further animals were kept for 28 days on food sprayed with "Elocron 50 WP". These animals were kept in quarantine during the period of treatment. The sialic acid level was found to be increased in the liver and in the other examined organs (heart, brain, kidney, lung) and slightly decreased in the serum. The aminohexose level was increased in the heart, kidney and brain, and decreased in the liver and lungs, in the early stage of intoxication (28 days) and in the group of the so-called "fodder" animals. In the late stage of the intoxication (85 days) an increased content of aminohexoses was observed in the brain and in the kidney, the increase was very slight in the heart and brain, whereas in the lung tissue the aminohexose level was subnormal.
对60只豚鼠进行“Elocron 50 WP”亚急性中毒实验，观察唾液酸和氨基己糖的变化情况。通过胃管将“Elocron 50 WP”溶于大豆油乳剂中，连续给药28天和85天，日剂量为1/3 LD50。另外，让动物食用喷洒有“Elocron 50 WP”的食物28天。在治疗期间，这些动物被隔离饲养。结果发现，肝脏及其他被检查器官（心脏、大脑、肾脏、肺）中的唾液酸水平升高，而血清中的唾液酸水平略有下降。在中毒早期（28天）以及所谓“饲料”组动物中，心脏、肾脏和大脑中的氨基己糖水平升高，肝脏和肺中的氨基己糖水平下降。在中毒后期（85天），大脑和肾脏中的氨基己糖含量增加，心脏和肝脏中的增加非常轻微，而肺组织中的氨基己糖水平低于正常。
