Rodionov I A
Vopr Med Khim. 1975 May-Jun;21(3):245-9.
In blood serum and tissues of rats with alimentary and antimetabolic thiamin deficiencies content of glycoproteins was determined. The alimentary B1-avitaminosis caused a decrease in content of ceruloplasmin, hexosamines and sialic acids in blood serum and also of hexosamines in liver tissue and aorta. In dificiency of thiamin, caused by a single administration of hydroxythiamin, content of hexosamines and sialic acids were decreased in liver, pancreas and heart; in blood serum content of ceruloplasmin was decreased but that of glycoproteins was increased. Thiamin increased content of glycoproteins and sialic acids in blood serum and the content of sialic acids in liver tissue, but it decreased content of hexosamines in liver and pancreas. Content of the metabolites studied in animals, maintained on avitaminous diet, was normalized by means of repeated administration of thiamin during four weeks.
