Simpson P B, Challiss R A, Nahorski S R
Dept of Cell Physiology and Pharmacology, University of Leicester, UK.
Trends Neurosci. 1995 Jul;18(7):299-306. doi: 10.1016/0166-2236(95)93919-o.
The intracellular concentration of free Ca2+ ([Ca2+]i) displays complex fluctuations in response to a variety of stimuli, and acts as a pluripotent signal for many neuronal functions. It is well established that various 'metabotropic' neurotransmitter receptors can mediate the mobilization of Ca2+ stores via actions of inositol-polyphosphate second messengers, and more recent evidence suggests that 'ionotropic' receptor-mediated Ca2+ signals in neurones might also involve release of Ca2+ from intracellular stores. These two mechanisms of release of Ca2+ enable considerable temporal and spatial complexity of increases in the [Ca2+]i via multiple interactions at the level of intracellular-receptor activation. The complexity of Ca2+ signalling that is elicited via these interconnecting pathways might underlie mechanisms that are central to information transfer and integration within neuronal compartments.
细胞内游离钙离子浓度（[Ca2+]i）会因各种刺激而呈现复杂波动，并作为多种神经元功能的多能信号。众所周知，各种“代谢型”神经递质受体可通过肌醇多磷酸第二信使的作用介导Ca2+储存库的动员，最近的证据表明，神经元中“离子型”受体介导的Ca2+信号也可能涉及细胞内储存库释放Ca2+。这两种Ca2+释放机制通过细胞内受体激活水平的多重相互作用，使[Ca2+]i升高具有相当大的时间和空间复杂性。通过这些相互连接的途径引发的Ca2+信号复杂性可能是神经元区室信息传递和整合核心机制的基础。
