Cornel E B, Smits G A, Debruyne F M, Heerschap A, Schalken J A, Oosterhof G O
Department of Urology, University Hospital, Nijmegen, The Netherlands.
Ultrasound Med Biol. 1995;21(2):243-8. doi: 10.1016/s0301-5629(94)00109-x.
The effects of repeated high-energy shock wave (HESW) tumor administration on tumor blood flow (TBF) were studied in NU-1 human kidney cancer xenografts. Deuteriated water was used as a magnetic resonance spectroscopic detectable tracer for measuring tumor blood flow. Tumors were exposed twice to 800 electromagnetically generated HESW, with a 24-h interval or sham exposed. No changes in TBF occurred after sham exposure to HESW. TBF levels 2 h after the first and second HESW application were, respectively, 46% and 37% lower than the mean preexposure TBF value and returned to normal levels within 16 h. There was statistically no difference found between the effects on tumor blood flow after the first and second HESW exposure. These observations are in agreement with earlier studies and provide a rationale to shorten the time interval between HESW monotreatments to 2 to 3 h.
在NU-1人肾癌异种移植物中研究了重复高能冲击波（HESW）肿瘤给药对肿瘤血流（TBF）的影响。使用重水作为磁共振波谱可检测的示踪剂来测量肿瘤血流。肿瘤接受两次800次电磁产生的HESW照射，间隔24小时，或进行假照射。假照射HESW后TBF没有变化。第一次和第二次HESW照射后2小时的TBF水平分别比照射前的平均TBF值低46%和37%，并在16小时内恢复到正常水平。第一次和第二次HESW照射后对肿瘤血流的影响在统计学上没有差异。这些观察结果与早期研究一致，并为将HESW单次治疗之间的时间间隔缩短至2至3小时提供了理论依据。
