Neau J P, Meurice J C, Paquereau J, Chavagnat J J, Ingrand P, Gil R
Institut Universitaire Veille-Sommeil, France.
Acta Neurol Scand. 1995 Jul;92(1):63-8. doi: 10.1111/j.1600-0404.1995.tb00468.x.
The association of habitual snoring with cerebral ischaemia was studied, in a case control-study, in 133 patients aged 45-75 years (103 men and 30 women) and 133 controls matched for sex and age. Ischaemic stroke was confirmed by brain computed tomography or magnetic resonance imaging. History of risk factors, especially of snoring and sleeping habits was recorded with structured questionnaire during interview. Prevalence of habitual snoring significantly differs between patients with stroke and controls: 31/133 (23.3%) vs 11/133 (8.3%) (Odds ratio 3.4, 95% confidence interval 1.5 to 7.6, p < 0.001). Even after adjusting for matching variables and confounding risk factors (arterial hypertension, cardiac arrhythmia, and obesity), habitual snoring carries a significant risk factor for stroke (odds ratio: 2.9, 95% confidence interval 1.3 to 6.8 (p = 0.01)). The risk of ischaemic stroke was higher among older male patients with arterial hypertension who always snored. Habitual snoring was not significantly linked with sleep-related stroke nor with the pathophysiology of strokes. Inquiring about habitual snoring should become a routine practice, especially among older male patients with arterial hypertension, and specific preventive measures should be instituted at an earlier stage.
在一项病例对照研究中，对133例年龄在45 - 75岁之间的患者（103名男性和30名女性）以及133名年龄和性别相匹配的对照者，研究习惯性打鼾与脑缺血之间的关联。通过脑部计算机断层扫描或磁共振成像确诊缺血性中风。在访谈期间，使用结构化问卷记录危险因素史，尤其是打鼾和睡眠习惯史。中风患者和对照者之间习惯性打鼾的患病率有显著差异：31/133（23.3%）对11/133（8.3%）（比值比3.4，95%置信区间1.5至7.6，p < 0.001）。即使在对匹配变量和混杂危险因素（动脉高血压、心律失常和肥胖）进行调整后，习惯性打鼾仍是中风的一个重要危险因素（比值比：2.9，95%置信区间1.3至6.8（p = 0.01））。在患有动脉高血压且经常打鼾的老年男性患者中，缺血性中风的风险更高。习惯性打鼾与睡眠相关中风以及中风的病理生理学均无显著关联。询问习惯性打鼾情况应成为常规做法，尤其是在患有动脉高血压的老年男性患者中，并且应在更早阶段采取具体的预防措施。
