急性非出血性卒中发病后6小时内的抗心磷脂抗体
Anticardiolipin antibodies in acute non-hemorrhagic stroke seen within six hours after onset.
作者信息
Camerlingo M, Casto L, Censori B, Drago G, Frigeni A, Ferraro B, Servalli M C, Radice E, Mamoli A
机构信息
2nd Neurological Department, Ospedali Riuniti, Bergamo, Italy.
出版信息
Acta Neurol Scand. 1995 Jul;92(1):69-71. doi: 10.1111/j.1600-0404.1995.tb00469.x.
INTRODUCTION
We have undertaken a prospective study to measure anticardiolipin antibodies of IgG isotype within the first few hours of an acute non-hemorrhagic stroke.
MATERIAL AND METHODS
We have collected blood samples at entry from one hundred patients (53 men and 47 women), mean age 67.4 years, referred within 6 h of a first-ever non-hemorrhagic stroke, and from an equal number of age- and gender-matched control patients.
RESULTS
IgG anticardiolipin antibodies were > or = 10 GPL in 26 patients and in 5 controls (p < 0.0001, X2 test). After logistic regression analysis, increase of IgG anticardiolipin antibodies remained independently associated with stroke (p = 0.0034), together with hypertension (p = 0.0009) and atrial fibrillation (p = 0.0238).
CONCLUSION
Our data suggest that the occurrence of elevation of IgG anticardiolipin antibodies in stroke patients should antedate stroke onset and might be a risk factor per se.
引言
我们进行了一项前瞻性研究，以测定急性非出血性卒中最初几小时内IgG同种型抗心磷脂抗体水平。
材料与方法
我们收集了100例患者（53例男性和47例女性，平均年龄67.4岁）在首次非出血性卒中6小时内入院时的血样，以及同等数量年龄和性别匹配的对照患者的血样。
结果
26例患者和5例对照者的IgG抗心磷脂抗体≥10 GPL（p<0.0001，卡方检验）。经逻辑回归分析后，IgG抗心磷脂抗体升高仍与卒中独立相关（p = 0.0034），同时还与高血压（p = 0.0009）和心房颤动（p = 0.0238）相关。
结论
我们的数据表明，卒中患者中IgG抗心磷脂抗体升高的情况应早于卒中发作，且其本身可能是一个危险因素。
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