适用于重症肌无力的可靠残疾量表，对临床变化敏感。
Reliable disability scale for myasthenia gravis sensitive to clinical changes.
作者信息
D'Alessandro R, Casmiro M, Benassi G, Rinaldi R, Gamberini G
机构信息
Epidemiologic Unit, University of Bologna, Italy.
出版信息
Acta Neurol Scand. 1995 Jul;92(1):77-82. doi: 10.1111/j.1600-0404.1995.tb00471.x.
INTRODUCTION
we developed a disability scale to monitor myasthenia gravis (MG) patients, based on degree of function impairment and daily frequency of each symptom.
MATERIAL & METHODS: the scale was based on standardized questions and clinical examination. The scale was administered to 12 patients, one or more times, for a total of 22 interviews. Each observation was recorded on videotape and reviewed by five independent observers. The ability of our scale to discriminate clinical changes was also compared with the Osserman classification.
RESULTS
our scale showed from substantial to almost perfect inter and intraobserver agreement. Our findings showed that clinically relevant changes not detected by Osserman staging were disclosed by our scale.
CONCLUSION
our scale is simple and easy to use in clinical practice. It offers an accurate means of evaluating disability in MG patients and may detect clinically relevant changes in disability. It would therefore be useful to monitor the effects of therapy.
引言
我们基于功能损害程度和每种症状的日常发生频率，开发了一种残疾量表来监测重症肌无力（MG）患者。
材料与方法
该量表基于标准化问题和临床检查。该量表对12名患者进行了一次或多次评估，共进行了22次访谈。每次观察都录制在录像带上，并由五名独立观察者进行审查。我们还将该量表区分临床变化的能力与奥斯勒曼分类法进行了比较。
结果
我们的量表显示观察者间和观察者内的一致性从实质性到几乎完美。我们的研究结果表明，我们的量表揭示了奥斯勒曼分期未检测到的临床相关变化。
结论
我们的量表在临床实践中简单易用。它提供了一种评估MG患者残疾情况的准确方法，并且可能检测到残疾方面的临床相关变化。因此，它对于监测治疗效果将是有用的。
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