Goetz C G, Stebbins G T, Shale H M, Lang A E, Chernik D A, Chmura T A, Ahlskog J E, Dorflinger E E
Department of Neurological Sciences, Rush Presbyterian St. Luke's Medical Center, Chicago, Illinois.
Mov Disord. 1994 Jul;9(4):390-4. doi: 10.1002/mds.870090403.
Although dyskinesia is a frequent and important problem in Parkinson's disease (PD), a reliable assessment measure has not been thoroughly developed and tested. We modified the Obeso dyskinesia scale to create an objective rating scale for dyskinesia assessment during activities of daily living. Thirteen physicians and 15 study coordinators involved in a clinical trial independently reviewed videotape segments of PD patients performing three tasks: walking, putting on a coat, and lifting a cup to the lips for drinking. Raters evaluated the severity of worst dyskinesia seen, the types of all dyskinesias seen, and the type of dyskinesia most associated with motoric disability. For all assessments, the total group showed statistically significant inter- and intrarater reliability. Physicians had a higher consistency than did coordinators, but for most measures the difference was not statistically significant. Physicians and coordinators found the scale easy to use and especially practical for rating dyskinesia severity and for identifying the most disabling dyskinesia. Dyskinesias can be assessed in clinical trials and warrant regular documentation.
尽管异动症在帕金森病（PD）中是一个常见且重要的问题，但尚未充分开发和测试出一种可靠的评估方法。我们对奥贝索异动症量表进行了修改，以创建一种用于在日常生活活动中评估异动症的客观评分量表。参与一项临床试验的13名医生和15名研究协调员独立审查了帕金森病患者执行三项任务（行走、穿外套、将杯子举到嘴边喝水）的录像片段。评分者评估了所观察到的最严重异动症的严重程度、所观察到的所有异动症的类型，以及与运动障碍最相关的异动症类型。对于所有评估，总体组在评分者间和评分者内均显示出具有统计学意义的可靠性。医生的一致性高于协调员，但对于大多数指标，差异无统计学意义。医生和协调员发现该量表易于使用，尤其适用于评估异动症严重程度和识别最具致残性的异动症。异动症可在临床试验中进行评估，并且需要定期记录。
