Abraham G, Waldron J J, Lawson J S
Kingston Psychiatric Hospital, Ontario, Canada.
Acta Psychiatr Scand. 1995 Aug;92(2):115-8. doi: 10.1111/j.1600-0447.1995.tb09553.x.
It has been claimed that the unwanted effects and toxicity of lithium can be minimized by changes in the dosing schedules. Twenty consecutive psychiatrically stable patients were investigated in a cross-over study to determine whether renal function and other biochemical tests change significantly with changes from once to twice or multiple doses per day or vice versa. There were no significant differences between the 3 study conditions on the mood rating scales or a side effect scale (UKU). Urine volume, test of renal function and other biochemical and hematological indices were similar in all study conditions. We thus conclude that dosing strategy does not consistently affect renal function in lithium-treated patients.
有人声称，通过改变给药方案可以将锂的不良影响和毒性降至最低。在一项交叉研究中，对20名连续精神状态稳定的患者进行了调查，以确定从每日一次给药改为每日两次或多次给药，或者反之，肾功能和其他生化检查是否会发生显著变化。在情绪评定量表或副作用量表（UKU）上，三种研究条件之间没有显著差异。在所有研究条件下，尿量、肾功能测试以及其他生化和血液学指标均相似。因此，我们得出结论，给药策略并不会持续影响接受锂治疗患者的肾功能。
