Litzman J, Dastych M, Hegar P
Inst. Clin. Immunol. Masaryk University, Brno, The Czech Republic.
Allergol Immunopathol (Madr). 1995 May-Jun;23(3):117-20.
Serum zinc, copper and iron levels together with content of zinc in hair were investigated in 13 patients with common variable immunodeficiency (CVID) and in 13 controls. A significant decrease in serum zinc (mean = 11.3 mumol/l, SD = 2.9 in CVID patients compared to mean 14.3 mumol/l, SD = 2.4 in controls) and iron levels (mean = 11.8 mumol/l, SD = 3.1 in CVID patients, mean = 18.3 mumol/l, SD = 4.7 in controls) in CVID patients were observed. Hair zinc content of CVID patients was significantly decreased compared to healthy persons (1.41 mumol/g, SD = 0.64 in CVID patients, and mean = 2.23 mumol/g, SD = 0.83 in controls). Serum copper level in CVID patients was significantly increased compared to controls (mean = 24.4 mumol/l, SD = 4.8 in CVID Patients, mean = 14.6 mumol/l, SD = 2.8 in controls). The decreased serum zinc and iron levels may be caused by disturbed absorption in the intestines of patients with CVID, but redistribution due to chronic inflammatory processes is a second possible explanation of hypozincemia in CVID patients.
对13例常见变异型免疫缺陷（CVID）患者和13名对照者的血清锌、铜和铁水平以及头发中的锌含量进行了研究。观察到CVID患者的血清锌水平（平均值=11.3μmol/L，标准差=2.9，而对照组平均值为14.3μmol/L，标准差=2.4）和铁水平（CVID患者平均值=11.8μmol/L，标准差=3.1，对照组平均值=18.3μmol/L，标准差=4.7）显著降低。与健康人相比，CVID患者的头发锌含量显著降低（CVID患者为1.41μmol/g，标准差=0.64，对照组平均值为2.23μmol/g，标准差=0.83）。与对照组相比，CVID患者的血清铜水平显著升高（CVID患者平均值=24.4μmol/L，标准差=4.8，对照组平均值=14.6μmol/L，标准差=2.8）。血清锌和铁水平降低可能是由于CVID患者肠道吸收紊乱所致，但慢性炎症过程导致的重新分布是CVID患者低锌血症的另一种可能解释。
